Liver Pathology: Steatohepatitis

Steatohepatitis is a common finding on liver biopsies. The main differential diagnosis is non-alcoholic steatohepatitis (NASH) versus alcoholic steatohepatitis. When the histologic and clinical findings are most consistent with NASH, the liver biopsies are graded and staged based on one of the following scoring systems: the Brunt system, the NASH Clinical Research Network (NASH CRN) system, and the SAF scoring system. Here, we discuss the evaluation of liver biopsies with steatohepatitis.