Is baclofen a good option for maintaining alcohol abstinence in patients with cirrhosis and alcohol use disorder?

Treatment of alcohol use disorder in patients with cirrhosis is essential. Here is one RCT assessing whether baclofen is a safe and effective option!

Brisk Hematochezia in Cirrhosis

61 year old male with alcohol-related cirrhosis presents with severe ascites. He had a therapeutic paracentesis with improvement in his ascites and underwent a surveillance EGD which showed large varices that were then banded. The following day, he developed tachycardia, hypotension, and hematochezia. A nasogastric tube was placed to suction without blood return.

What is the most likely etiology of the bleed?

Pathology Pearls Post 8: Primary Sclerosing Cholangitis (PSC)

Primary sclerosing cholangitis (PSC) is a primary biliary disorder characterized by progressive destruction of bile ducts. In this post we will present the most classic microscopic findings of PSC, while discussing the challenges of making this diagnosis solely based on histology.

Nutritional Management of the Child with Cirrhosis

A 5 month old FT baby boy presented with a five day history of abdominal distention, jaundice and was found to have significant ascites and elevated AFP. Laboratory evaluation was significant for hypoalbuminemia (albumin-1.8 g/dL), coagulopathy (INR-3.5) and elevated alpha-feto protein (23,300 ng/mL). Whole exome sequencing was non-diagnostic and he was diagnosed with cryptogenic cirrhosis. During his admission his ascites is refractory to both medical therapy and repeat paracentesis. He is listed for liver transplant. Of the following, what is the best predictor of post-transplant mortality and graft survival?