The Real Deal Behind Alagille Syndrome Background Alagille syndrome is an autosomal dominant, multisystem disorder with characteristic hepatic, cardiac, vascular, renal, skeletal, ocular, and facial…
Children are not small adults and thus their immune system is much more sophisticated… Check out the seminal iWITH trial establishing that in selected pediatric…
NAFLD is a widespread etiology for liver disease in the pediatric population; however the gold standard for diagnosis, a liver biopsy, is an invasive procedure.…
In a very special installment of the Why Series, our adult and pediatric teams join forces to answer the question of how living donor liver transplantation came about in the United States. Read on!
What new condition should be considered and worked up in patients with pediatric acute liver failure of unknown origin?
Learn about the diagnostic approach to cholestasis in pediatrics, focused on a case of a 5-day-old baby with persistence jaundice and hyperbilirubinemia.
A 5 month old FT baby boy presented with a five day history of abdominal distention, jaundice and was found to have significant ascites and elevated AFP. Laboratory evaluation was significant for hypoalbuminemia (albumin-1.8 g/dL), coagulopathy (INR-3.5) and elevated alpha-feto protein (23,300 ng/mL). Whole exome sequencing was non-diagnostic and he was diagnosed with cryptogenic cirrhosis. During his admission his ascites is refractory to both medical therapy and repeat paracentesis. He is listed for liver transplant. Of the following, what is the best predictor of post-transplant mortality and graft survival?