Steatohepatitis is a common finding on liver biopsies. The main differential diagnosis is non-alcoholic steatohepatitis (NASH) versus alcoholic steatohepatitis. When the histologic and clinical findings are most consistent with NASH, the liver biopsies are graded and staged based on one of the following scoring systems: the Brunt system, the NASH Clinical Research Network (NASH CRN) system, and the SAF scoring system. Here, we discuss the evaluation of liver biopsies with steatohepatitis.
Why do patients get liver biopsies? The main goals of a liver biopsy are to (1) render a diagnosis in a patient with abnormal liver function tests (LFTs) or a liver lesion on imaging, (2) provide staging and grading in a patient with a history of chronic hepatitis, (3) assess the liver’s response to treatment, and (4) assess the function of a liver transplant.